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KMID : 0043319980210010024
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Archives of Pharmacal Research
1998 Volume.21 No. 1 p.24 ~ p.29
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A Potent Anti-diabetic Agent from Kalopanax pictus
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Park Hee-Juhn
Park Jong-Hee
Han Yong-Nam
Kim Dong-Hyun
Choi Jong-Won
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Abstract
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To search for the anti-diabetic principle from the stem bark of Kalopanax pictus, seven kinds of chemical constituents including hederagenin glycosides and phenolic glycosides wre isolated. The anti-diabetic evaluation of these isoltes in the streptozotocin-induced diabetic rats exhibited that kalopanaxsaponin A has a potent anti-diabetic activity in contrast to a mild activity of hederagenin. In addition, significant hypocholesterolemic and hypolipidemic activities of kalopanaxsaponin A and hederagenin were observed. The structure-activity relationship of kalopanaxsaponin A was also investigated in the present work.
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KEYWORD
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Kalopanx picus, Araliaceae, Anti-diabetic, Kalopanaxsaponin A, Hedearagenin
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